SeroVital HGH Review

By: Jenni

Is SeroVital HGH the secret to staying young?

That’s what advertisements would have you believe!

There’s no question increasing HGH levels, can help you experience a significant improvement in your overall health as well as a number of additional benefits.

According to, “It’s clear that Growth Hormone has been associated with wrinkle reduction, decreased body fat, increased lean muscle mass, stronger bones, improved mood, heightened sex drive, and making users look and feel decades – not years, but DECADES – younger”

But will SeroVital really help you see those kind of benefits?

I’ve been conditioned to have my doubts on just about every supplement out there, so I took a closer look at what SeroVital could really do. . .

Is SeroVital Clinically Proven?

SeroVital is impressing medical and cosmetic experts alike with its latest research, which is available on the official website.

In this research, healthy subjects were given an amino acid combination or a placebo. Within 120 minutes, those who received the compound experienced an 8 fold increase from their HGH baseline.

“Overall, we report an eight-fold increase, equivalent to 682%, in GH levels 120 minutes after a single oral supplement of SeroVital.”

However, I can’t help but be a little skeptical of the results. The study, though listed publically on the website, does not appear in any peer-reviewed journal.

Additionally, the study was obviously sponsored by SeroVital manufacturers, and it’s possible the results were slanted in the product’s favor.

And last, but not least, 682% may seem like a large number, but it still doesn’t compare to HGH injections.

“Even if this product works as claimed,” explains Dr. Petter Griffiths, “their own study admits it is equivalent to 0.06iu of injected GH, a dose which anyone who has used real injected GH will tell you has virtually no fat loss effects.” [1]

Consequently, I’m not completely sold on SeroVital based on the lead study alone. I needed to investigate its individual ingredients to determine its overall potential.

Do The Ingredients Back It Up?

To start, consumers should note that SeroVital does not contain any HGH.

“To call our formula an ‘HGH pill’ is a misnomer,” says Dr. Amy Deaton, PhD.“SeroVital™-hgh is not human growth hormone in pill form. . . rather than making your body dependent on an outside source of the hormone, SeroVital provides a more natural way of increasing serum (blood) HGH levels in the body.” [2]

Like many other HGH releasers, SeroVital depends on amino acids to stimulate the pituitary gland and promote HGH production.

Lysine. This amino acid plays a key role in muscle building, enzyme and hormone production, and calcium absorption.

It works synergistically with arginine to stimulate HGH production, but only in doses of 1200 mg or more. When used separately or in smaller concentrations, lysine has little or no effect on HGH. [3]

Arginine. Arginine is a nutrient precursor to nitric oxide. When nitric oxide levels are increased, blood vessels relax and widen, improving circulation and flow.

Researchers found 5-9 mg arginine increases resting HGH levels by as much as 100%. When combined with exercise, this amount doubles to 200%. [4]

However, scientists also found “this increase may be less than seen with exercise alone.” So you may end up getting better HGH results by simply exercising than supplementing with arginine.

Oxo-Proline. Oxo-proline is an amino acid derivative of glutamic acid. Studies suggest it transports other amino acids across the blood-brain barrier, accelerating the initial rate of “substrate transport by the two sodium-dependent amino acid carriers.”

Researchers believe oxo-proline may be “an important link in the short term control of sodium-dependent amino acid transport.” [5]

Consequently, it would be easy to assume oxo-proline would work synergistically with amino acids such as lysine HCI and arginine HCI.

However, these amino acids were not featured in the study, and additional research suggests oxo-proline elicits oxidative stress, damaging cell DNA. [6]

With such conflicting studies, none of which mention HGH, I’m surprised oxo-proline was included in the formula.

N-Acetyl L-Cysteine. This stable cysteine form is primarily used to eliminate free radicals and prevent side effects induced by drug reactions (such as acetaminophen poisoning).

University of Maryland Medical Center experts suggest taking 500 mg to improve overall health and protect against free radicals, but there is not enough information to know if SeroVital contains this amount.

Schizonepeta. Scientists are currently investigating schizonepeta’s ability to inhibit allergic reactions.

Animal studies suggest high schizonepeta doses may reduce inflammatory response by regulating cytokine release. [7]

While this is promising, there is not enough evidence to confirm any potential impact on HGH production.

What Consumers are Really Saying About SeroVital

HGH injections are only given to individuals with an HGH deficiency. In fact, many of the promised HGH benefits are a direct result of bringing HGH levels up to a healthy range.

Scientists are still investigating what that range should be, however, and its effects on already healthy individuals are unknown.

Yet with all the hype about HGH, many consumers automatically assume increasing HGH will help them stay young and healthy forever.

Increasing HGH production by stimulating the pituitary gland may provide some small benefit, but not as much as consumers might think. Furthermore, it may take months or even years before consumers notice a difference at all.

Consequently, when users turn to SeroVital to improve BMI or build muscle, they are often disappointed with their overall results.

Jacked at wrote, “I have used this product for almost 2 weeks and have not seen a single change or improvement in the way I look or feel. It’s expensive and offers end results which are surely a lure only to buy the product. I will not buy this product again.”

Robin also adds, “I’ve been taking this for 2 weeks without seeing any changes at all; skin, weight, energy, and sleep quality have not changed a bit. I can’t find anything on how long it is supposed to take before results.”

Should You Be Worried About Side Effects?

Compared to other supplements, SeroVital’s die effect risk is fairly low. There are no unproven chemicals. No harsh stimulants. No filler or “fluff” ingredients.

But don’t let this fool you into thinking it’s completely safe for everyone.

The ingredient concentrations are hidden behind a proprietary blend, so it’s impossible to tell if the ingredients are in their clinically proven and safe concentrations.

Arginine is known to cause side effects such as bloating, diarrhea, stomach upset, abdominal pain, and allergies.

Facebook girl at wrote, “Took as directed and my tummy bloated so bad. Causes gas and that is not good ! Did not feel any changes!”

I suspect these side effects were a direct result of high arginine concentrations.

There is even a concern that arginine may increase the risk of death after a heart attack, especially in older adults.

If you recently had a heart attack, or are taking medication to improve heart health, then consult your doctor before using SeroVital to make sure it’s safe for you.

Getting the Most Out of SeroVital

As with any supplement SeroVital works best when combined with a healthy diet and regular exercise. It’s designed to enhance already healthy lifestyles, not compensate for poor decisions.

According to manufacturers, you should take SeroVital on an empty stomach so the amino acids found in food won’t interfere with the ingredients found in the formula.

The best time to take SeroVital is in the morning at least 2 hours before breakfast or in the evening at least 2 hours after your last meal of the day.

Do not take more than 4 capsules in a 24 hour period. Increasing your dosage will only increase your side effect risk, not your results.

Where to Find the Best Deals

SeroVital can be purchased from or from for $99 a bottle. This is a lot more than many customers are willing to pay, but despite this, manufacturers are still having problems keeping SeroVital in stock.

“With all the recent media coverage, sales have gone through the roof and our suppliers have been having trouble keeping up,” stated Kerry Pack, a communications specialist with Sierra Research Group.[9]

Fortunately, you don’t have to pay full price if you sign up for the autoship program. If you click on the preferred customer plan, you will automatically be billed $80 every 30 days for a new bottle of SeroVital. This price includes shipping handling, saving you up to $25.95 per order.

Then again, consumers should always exercise caution when dealing with an autoship program, as cancelling may be difficult.

Other diet pill companies are notorious for making unwanted credit card charges and ignoring customer complaints about discontinuing shipments. Whether SeroVital manufacturers will follow suit has not been determined.

Who Is the Sierra Research Group?

The Sierra Research Group is a Utah-based company focused on providing new technology, compounds, and products for cosmetic and dietary supplement companies.

According to the official website, “Sierra has scoured the globe and partnered with some of the foremost experts in the fields of weight loss, anti-aging, and wellness, to produce groundbreaking research studies on the menstrual cycle and weight loss, growth hormone, energy expenditure and metabolism, and appetite suppression, just to name a few.”

This group originally created the SeroVital formula, but then licensed three companies to use the technology: SanMedica (SeroVital), Novex Biotech (Growth Factor 9), and Alpha Gen Biotech (yet to be released).


• Does not contain caffeine or other stimulants
• Utilizes all-natural ingredients
• Highly recommended by experts
• Does not require a prescription


• Might not work for everyone
• Undisclosed ingredient concentrations
• Company is too new – hasn’t proven itself to be reliable
• Clinical study not published in peer-reviewed journal

Should You Buy SeroVital?

Despite all its hype, I’m not convinced SeroVital is the best method for increasing HGH. The formula utilizes popular amino acids rather than clinically proven ingredients. The research is limited and the customer feedback suggests SeroVital is not as strong as advertisers let on.

For $100 a bottle, SeroVital doesn’t seem worth the investment. Although it may improve your overall health and performance over time, the risks outweigh the benefits.


[1] “New Serovital HGH Product?” Iron Magazine. Nov. 11, 2012. Available from:

[2] “Sierra Research Group Officially Licenses new ‘Youth Pill.’” Sierra Research Group News. Sept. 21, 2012. Available from:

[3] Isidori A, Lo Monaco A, Cappa M. “A study of growth hormone release in man after oral administration of amino acids.” Curr Med Res Opin. 1981;7(7):475-81. Available from:

[4] Kanaley JA. “Growth hormone, arginine and exercise.” Curr Opin Clin Nutr Metab Care. 2008 Jan;11(1):50-4. Available from:

[5] Wha-Joon Lee, Richard A. Hawkins, Darryl R. Peterson and Juan R. Viña. “Role of Oxoproline in the Regulation of Neutral Amino Acid Transport across the Blood-Brain Barrier.” August 9, 1996 The Journal of Biological Chemistry, 271, 19129-19133. Available from:

[6] Carolina D Pederzolli, Angela M Sgaravatti, César A Braum, Cristina C Prestes, Giovanni K Zorzi, Mirian B Sgarbi, Angela T S Wyse, Clóvis M D Wannmacher, Moacir Wajner, Carlos S Dutra-Filho. “5-Oxoproline reduces non-enzymatic antioxidant defenses in vitro in rat brain.” Metabolic Brain Disease (impact factor: 2.2). 04/2007; 22(1):51-65. DOI:10.1007/s11011-006-9041-2 Available from:

[7] “Cysteine.” University of Maryland Medical Center. Available from:

[8] Kang, H; Oh, YJ; Choi, HY; Ham, IH; Bae, HS; Kim, SH; Ahn, KS (2008). “Immunomodulatory effect of Schizonepeta tenuifolia water extract on mouse Th1/Th2 cytokine production in-vivo and in-vitro”. The Journal of pharmacy and pharmacology 60 (7): 901–7. doi:10.1211/jpp.60.7.0012. Available from:

[9] Johnsen, Michael. “Sierra Research Labs licenses distribution of SeroVital-hgh through GNC to Novex Biotech.” Drug Store News. Dec. 27, 2012. Available from:

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SeroVital HGH User Reviews

4 Reviews  | Write a Review

  1. Comment

    Took this for 3 months. No results! Too expensive to keep trying.

    Shirley Mccauley
    June 15, 2013 at 9:56 am
  2. Comment

    I’ve only used this product for 1 week. The only change that I’ve noticed is that my skin has become very itchy. There are also small bumps that have appeared on my arms. I didn’t expect this reaction and I’m very disappointed in this drug.

    Debbie Harper
    June 19, 2013 at 6:35 am
  3. Comment

    I have been taking it for 6 months and have had very good results.
    Muscle tone is better, I have had weight loss, My skin feels good, not that I have noticed my wrinkles softening, but over all skin tone looks better on my face. I do exercise on a regular bases and eat a healthy diet. And have maintain taking SeroVital on a empty stomach as stated. I am happy with it and will continue to take it.

    Annie Wilcox
    August 14, 2013 at 8:11 am
  4. Comment

    I have been taking SeroVital for about 5 months. First month I just noted I slept better and my skin seemed brighter and less blotchy. I watch my diet and exercise and I believe my muscle tone is more defined. I have always exercised but have not been able to define my muscles as much as I do now. The expense is a little high but I feel good so will continue for now. The changes are subtle so you kind of wonder is it the sero or just my own diet and exercise…

    Peggy Maier
    October 12, 2013 at 6:10 am

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